| 刘应乐 姓名：刘应乐 出生年月：1986-10 职称：教授 电子邮箱：liuyingleyou@163.com 通讯地址：四川轻化工大学汇东校区第二实验楼4101 | 性别：男 学位：博士 联系电话：0813-5505653 传真： 邮编：643000 |
个人描述
硕士生导师，入选盐都百千万英才计划、宜宾市引进高层次人才项目。主要承担本科学生《有机化学》《有机氟化学》、硕士研究生《化学前沿》课程的教学工作。获四川省教学成果奖2项(分别排名第三和第五)，校级教学成果奖特等奖1项(排名第1)；主持省级教学改革项目1项，创新性实验项目1项；多次获校级“优秀共产党员”、“颜德岳院士奖教金”、“优秀硕士研究生指导教师”、“我心目中的好老师”、“优秀教师”等荣誉称号。目前已指导化学、药学或材料化工硕士研究生16人，其中已毕业9人，2人获校级优秀硕士论文。
学习及工作经历
1.2005.09- 2009.07，吉首大学，学士；
2.2009.09 - 2014.04，东华大学，博士；
3.2014.04 - 2017.01，四川轻化工大学，讲师；
4.2017.01 - 2022.01，四川轻化工大学，副教授；
5.2018.01 - 2019.01，美国爱达荷大学，访问学者；
6.2019.12 -2021.12，四川大学-宜宾天原集团股份有限公司，博士后；
7.2022.01 -迄今，四川轻化工大学，教授。
主要研究领域
1.结合有机合成化学、晶体工程学、计算化学等进行新型富氮含能材料的合成与计算，探索其在猛炸药、耐热炸药、身管武器发射药、火箭推进剂中的应用。
2.结合氟原子或含氟基团的独特性质(电子、脂溶性等)及药物分子结构与活性关系分析，进行生理活性化合物的含氟类似物合成方法学及活性筛选研究。
3.依托宜宾特种经济林油樟资源，开展油樟精油有效功能组分的高值化应用及转化研究。
主持或参与的科研项目
1. 新型高能低感1,2,4,5-四嗪稠环单质炸药的合成与性能研究，国家自然科学青年基金，主持。
2. 新型偕二硝甲基富氮稠环含能材料的设计、合成及其性能研究，国家自然科学基金面上项目，联合申报单位主持人。
3. 1,2,4,5-四嗪稠环单质炸药的合成与性能研究，中国博士后科学基金面上项目，主持。
4. 降脂药物依替米贝的创新合成技术及工艺研究，四川省科技厅应用基础项目，主持。
5. 高能低感三唑并四嗪联稠环含能材料的合成与性能研究，四川省科技厅自然科学青年基金，主持。
6. 油樟精油有效成分的提取关键技术及其在日用化学品中的高值应用研究，宜宾市引进高层次人才，主持。
7. 盐都科技菁英，自贡市高层次人才，2019年，主持。
8. 新型烯基异氰的氟烷基化自由基串联反应研究，四川省人力资源与社会保障社厅，主持。
9. 氟烷基取代螺环氧化吲哚化合物的合成研究，合成化学与污染控制四川省重点实验室，主持。
10. 含氮杂环阴离子类离子盐作为新型缓蚀剂的研究，材料腐蚀与防护四川省重点实验室，主持。
11. 油樟精油类中高端日化品的研发与持续改进研究，横向，主持。
12. 多氟醇/胺原料定制，横向，主持。
13. 基于N-N键延长策略用于合成高氮含能化合物，横向，主持。
14. 聚酰亚胺泡沫单体合成工艺-II，横向，主持。
15. 基于氟气条件下的杂环氮氧化合物的合成研究，横向，主持。
代表性论著
1. Yizhen Feng, Yaqun Dong, Qiangqiang Liu, Yingle Liu,* Ziwu Cai.* Electronic structure rearrangement via nitroamine–nitroimine tautomerism: obtaining thermally stable and low-sensitivity nitrogen-rich nitroamine energetic materials. Organic Letters, 2026, 28(12): 3718-3723.
2. Kuo Zhao, Wenjie Liu, Yu Huang, Qian Wu, Yingle Liu,* Huichuang Guo,* Enxue Shi.* Tandem Arbuzov-Perkow reaction: general synthesis of α-substituted vinyl P(V)-compounds. Organic & Biomolecular Chemistry, 2026, 24(6)： 1257-1262.
3.Shuai Liu,#Jun Zhou,# Lu Yu,# Yingle Liu,# Yangen Huang,* Yao Ouyang,* Guo-Kai Liu,* Xiu-Hua Xu,* Norio Shibata.* Nitrogen-based organofluorine functional molecules: synthesis and applications. Chemical Reviews, 2025, 125(9)：4603-4764.
4. Xiaoyu Guo, Yizhen Feng, Yingle Liu,* Qiangqiang Liu, Li-qiong Luo, Haixiang Gao.* Constructing high-energy insensitive fused-ring energetic materials via a strategy of maximizing the heat of formation. Journal of Materials. Chemistry A, 2025,13(15)： 10782-10791.
5. Yajie Fu, Hexia Ye, Xinyao Zhao, Yingle Liu,* Junchen Li,* Xiaojing Bi.* Metal- and solvent-free synthesis of phosphinothioates, phos-phonothioates, phosphorothioates, and related selenium derivatives: an efficient green protocol. Molecules 2025, 30(10): 2097-2112.
6. Xiaoyu Guo,#Yizhen Feng,# Shengjie Zhi, Yajie Fu, Yingle Liu,* Qiangqiang Liu, Haixiang Gao.* Obtaining superior high-density fused-ring energetic materials via the introduction of carbonyl, o-NH2-NO2 and nitroamino groups. Dalton Transactions, 2024, 53(9): 4035-4040.
7.Pei⁃dong Yu, Qiang⁃qiang Liu, Xiao⁃yong Ding, Ying⁃le Liu,* Gao Hai⁃xiang.* Intriguing fluorine effect：an important factor for effective construction insensitive energetic materials. Chinese Journal of Energetic Materials, 2024, 32(6):641-650.
8. Ming-yu Yuan, Qiang-qiang Liu, Yu Shang, Wei Zhou, Li Zou, Haixiang Gao,* Yingle Liu.* Solubility and Dissolution Thermodynamics of Molecular Perovskite Energetic Material. Chinese Journal of Energetic Materials, 2023, 31(11): 1116-1123.
9. Qiang-qiang Liu,# Han Wang,# Yun-jie Kang, Ying-le Liu,* Pei-dong Yu, Ming-yu Yuan, Hai-xiang Gao.* Obtaining advanced insensitive energetic materials by regioselectively introducing N-oxide groups onto 6-trifluoromethyl-1,2,4,5- tetrazine-3-amine. Energetic Materials Frontiers, 2023, 4: 30-36.
10. Qiangqiang Liu,# Mingyu Yuan,# Jinghua He, Peidong Yu, Xiaoyu Guo, Yingle Liu,* Haixiang Gao,* Ping Yin.* Exchanging of NH2/NHNH2/NHOH groups: An effective strategy for balancing the energy and safety of fused-ring energetic materials. Chemical Engineering Journal, 2023, 466:143333-143342.
11.Yunjie Kang,# Yuting Dong,#Yingle Liu,* Haixiang Gao,* Yi Wang,* Jean'ne M. Shreeve.* Halogen bonding (C-F...X) and its effect on creating ideal insensitive energetic materials. Chemical Engineering Journal, 2022, 440: 135969-135978.
12.Han Wang, Yingle Liu,* Qiangqiang Liu, Yunjie Kang, Mingyu Yuan, Min An, Haixiang Gao,* Qinghua Zhang, Yi Wang.* Hydrogen bonding distribution and its effect on sensitivity of planar tricyclic polyazole energetic materials. Chemical Engineering Journal, 2022, 433: 1334479-1334487.
13.Juan Fang,# Tao Yang,# Min An, Yingle Liu,* Yi Liu,* Yi Yang,* Jie Zhou, Ting Cao, Qijun Ren, Hui Huang.* Design, synthesis and biological evaluation of difluoroalkylated protoilludanes obtained by a practical radical cascade difluoroalkylation-cyclization reaction. Tetrahedron Letters, 2022, 89: 153594-153598.
14.Yingle Liu,* Yunjie Kang, Han Wang, Yuting Dong, Tao Yang, Qinqin Wei, Yan Jiang, Yi Yang,* Haixiang Gao.* Merging single-electron transfer and energy transfer processes of photocatalyst: An atom economical strategy for the synthesis of 1-trifluoroethylated isoquinolines from cis and trans vinyl isocyanides. Tetrahedron Letters, 2020, 61(38): 152348-152353.
15.Yingle Liu,* Gang Zhao, Yongxing Tang, Jichuan Zhang, Lu Hu, Gregory H. Imler, Damon A. Parrish, Jean'ne M. Shreeve.* Multipurpose [1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine-based energetic materials. Journal of Materials Chemistry A, 2019, 7(13): 7875-7884.
16.Yingle Liu,* Gang Zhao, Qiong Yu, Yongxing Tang, Gregory H. Imler, Damon A. Parrish, Jean'ne M. Shreeve.* Intermolecular weak hydrogen bonding (Het-H-N/O): an effective strategy for the synthesis of monosubstituted 1,2,4,5-tetrazine-based energetic materials with excellent sensitivity. Journal of Organic Chemistry, 2019, 84(24): 16019-16026.
17.Yingle Liu,* Tao Yang, Yuting Dong, Junjie Cai, Gen Luo, Xia Tong, Yan Jiang, Yi Yang,* Xiu-Hua Xu.* Selective cleaving the Nsingle bondP bond of difluoromethylene phosphabetaines for effective synthesis of β-ketoamides. Tetrahedron Letters, 2019, 60(29): 1934-1937.
18. Yi Yang,* Junjie Cai, Gen Luo, Yan Jiang, Yumei Su, Yang Su, Chaolin Li, Yubin Zheng, Jijiao Zeng, Yingle Liu.* Nickel-catalyzed fluoroethylation of arylboronic acids via Suzuki-type coupling. Organic Chemistry Frontiers, 2019, 6(9): 1463-1470.
19. Yingle Liu,* Chunlin He, Yongxing Tang, Gregory H. Imler, Damon A. Parrish, Jean'ne M. Shreeve.* Tetrazolyl and dinitromethyl groups with 1,2,3-triazole lead to polyazole energetic materials. Dalton Transactions, 2019, 48(10): 3237-3242.
20.Yingle Liu,* Chunlin He, Yongxing Tang, Gregory H. Imler, Damon A. Parrish, Jean'ne M. Shreeve.* Asymmetric nitrogen-rich energetic materials resulting from the combination of tetrazolyl, dinitromethyl and (1,2,4-oxadiazol-5-yl)nitroamino groups with furoxan. Dalton Transactions,2018, 47(46):16558-16566.
21.Yingle Liu,* Ke Zhang, Weidong Jiang, Yi Yang, Yan Jiang, Xiaoqiang Liu, Ying Xie, Jincai Wu, Junjie Cai, Xiu-Hua Xu.* Synthesis of 1-difluoroalkylated isoquinolines via palladium-catalyzed radical cascade difluoroalkylation-cyclization of vinyl isocyanides with bromodifluoroacetic derivatives. Chemistry-an Asian Journal, 2017, 12(5): 568-576.
22. Yingle Liu,* Ke Zhang, Yangen Huang, Shen Pan, Xiao-Qiang Liu, Yi Yang, Yan Jiang, Xiu-Hua Xu.* Synthesis of 3-fluoroalkenyl-3-trifluoromethyl-2-oxindoles by the reaction of indoline-2,3-diones with difluoromethylene phosphabetaine. Chemical Communications, 2016, 52(35): 5969-5972.
23. Yingle Liu, Yi Yang, Yangen Huang, Xiu-Hua Xu, Feng-Ling Qing.* Regio- and Diastereoselective Vinylogous Mannich Addition of 3-Alkenyl-2-oxindoles to α-Fluoroalkyl Aldimines. Synlett, 2014, 26(01): 67-72.
24. Yingle Liu, Jun-Ling Chen, Gai-Hong Wang, Peng Sun, Heyao Huang, Feng-Ling Qing.* 4-CF3-ezetimibe analogs: design, synthesis, and biological evaluation of cholesterol absorption inhibitions. Tetrahedron Letters, 2013, 54(40): 5541-5543.
25.Yingle Liu, Jiawang Liu, Yangen Huang, Feng-Ling Qing.* Lewis acid-catalyzed regioselective synthesis of chiral a-fluoroalkyl amines via asymmetric addition of silyl dienolates to fluorinated sulfinylimines. Chemical Communications, 2013, 49(68): 7492-74944.
26.Yingle Liu, Yangen Huang*, Feng-Ling Qing. Asymmetric synthesis of β-aryl-β-trifluoromethyl-β-aminoarones via Mannich-type reactions of ketone enolates with chiral aryl CF3-substituted N-tert-butanesulfinyl ketimines. Tetrahedron, 2012, 68(25): 4955-4961.
获奖及社会兼职
1. 获自贡市自然科学优秀论文一、二、三等奖各一项(均排名第一)；
2. 指导学生获省级化学竞赛一、二、三等奖校多项；
3. 《Chemical Engineering Journal》等期刊审稿人。
专利
1. 刘应乐；董宇婷；白豪，一类含氟[1,2,4]三唑[4,3-b][1,2,4,5]四嗪硝铵及其制备方法，已授权。
2. 刘应乐；安敏；余沛东，一种吡唑并嘧啶酮单质炸药及其制备方法，已授权。
